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(2S,3S)-1,4-Dioxaspiro[4.5]decane-2,3-diylbis(diphenylmethanol)

  • CAS No. 123287-35-4

  • Cat. No. CS-0086939
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2S,3S)-1,4-Dioxaspiro[4.5]decane-2,3-diylbis(diphenylmethanol)|CS-0086939

Structure of 123287-35-4

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General Information

  • CAS No. 123287-35-4
  • Cat. No. CS-0086939
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₄H₃₄O₄
  • Molecular Weight 506.63
  • Synonym(s) (2S,3S)-α2,α2,α3,α3-tetraphenyl-1,4-Dioxaspiro[4.5]decane-2,3-diMethanol
  • SMILES OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@@H]3[C@@H](C(C4=CC=CC=C4)(C5=CC=CC=C5)O)OC6(CCCCC6)O3

Description

This spirocyclic diol features a rigid, electron-rich scaffold with two diphenylmethyl-protected hydroxyl groups. The (2S,3S) stereochemistry ensures predictable stereoselective reactivity in asymmetric synthesis, while the dioxaspiro core provides exceptional bench stability and moisture tolerance. Ideal for constructing complex molecular architectures in medicinal chemistry and natural product synthesis.

Application

(2S,3S)-1,4-Dioxaspiro[4.5]decane-2,3-diylbis(diphenylmethanol) serves as a rigid, chiral bis-protecting group scaffold enabling stereoselective transformations in complex molecule synthesis. Its spirocyclic architecture provides enhanced stability and orthogonal reactivity, facilitating efficient functionalization and purification in multi-step synthetic sequences. The diphenylmethyl (benzhydryl) moieties offer robust protection for diols and amines under standard conditions, while the defined stereochemistry supports asymmetric synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.92
  • LogP   6.303
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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