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CS-W001157 4
Total: USD 88.00

(2-(2-Hydroxyethyl)phenyl)boronic acid

  • CAS No. 1232424-23-5

  • Cat. No. CS-0121080
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-(2-Hydroxyethyl)phenyl)boronic acid|CS-0121080

Structure of 1232424-23-5

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General Information

  • CAS No. 1232424-23-5
  • Cat. No. CS-0121080
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₃
  • Molecular Weight 165.98
  • Synonym(s) None
  • SMILES OB(C1=CC=CC=C1CCO)O

Description

This boronic acid features a hydroxyethyl-substituted phenyl ring, enhancing solubility and stability in aqueous environments. The pendant hydroxyl group facilitates hydrogen bonding and improves handling under standard bench conditions. Designed for efficient coupling reactions, it integrates readily into Suzuki-Miyaura transformations and other cross-coupling protocols requiring moisture-tolerant boron reagents.

Application

(2-(2-Hydroxyethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-hydroxyl group facilitates chelation control and enhances regioselectivity in transition-metal-catalyzed transformations. The compound exhibits good bench stability, moderate solubility in common organic solvents, and compatibility with diverse functional groups, making it well-suited for iterative synthesis of complex biaryl architectures and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0988
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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