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(S)-2-(4-Bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

  • CAS No. 1228565-84-1

  • Cat. No. CS-0376012
  • Molecule weight330.17
  • Purity≥98%
  • MDL No.MFCD07371737

*For research and further manufacturing use only, not for direct human use.

(S)-2-(4-Bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid|CS-0376012

Structure of 1228565-84-1

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General Information

  • CAS No. 1228565-84-1
  • Cat. No. CS-0376012
  • Purity ≥98%
  • MDL No. MFCD07371737
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆BrNO₄
  • Molecular Weight 330.17
  • Synonym(s) Boc-(S)-2-amino-2-(4-bromophenyl)acetic acid
  • SMILES CC(C)(C)OC(N[C@@H](C1=CC=C(C=C1)Br)C(O)=O)=O

Description

(S)-2-(4-Bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid is a chiral building block featuring a brominated aryl group and a protected amino functionality. This scaffold enables direct incorporation into peptide sequences or conjugation workflows, offering stability under standard conditions and compatibility with diverse synthetic transformations.

Application

(S)-2-(4-Bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid serves as a key chiral building block for the synthesis of pharmaceutically relevant arylalanine derivatives. The protected α-amino acid functions effectively in standard peptide coupling protocols, offering bench-stable handling and orthogonal deprotection via acidic conditions. Its brominated aromatic moiety enables downstream cross-coupling transformations, facilitating the construction of complex heterocyclic and biaryl scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.0995
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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