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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-6-methylpyridine

  • CAS No. 1227579-04-5

  • Cat. No. CS-0443059
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-6-methylpyridine|CS-0443059

Structure of 1227579-04-5

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General Information

  • CAS No. 1227579-04-5
  • Cat. No. CS-0443059
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₂N
  • Molecular Weight 129.11
  • Synonym(s) 2,3-difluoro-6-methyl-pyridine
  • SMILES CC1=NC(=C(C=C1)F)F

Description

2,3-Difluoro-6-methylpyridine offers a strategically positioned trifluoromethyl-like electronic profile with enhanced stability. The ortho-fluorine substituents deliver strong electron-withdrawing effects, while the methyl group at C6 provides steric and electronic modulation. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive heterocycles.

Application

2,3-Difluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling site-selective functionalization via directed ortho-metalation. Its fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties for drug candidates. The methyl group offers a handle for further derivatization, while the difluoro substitution pattern enhances lipophilicity and membrane permeability. This compound exhibits bench stability and compatibility with standard cross-coupling protocols, facilitating integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.66822
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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