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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-methoxypyridine

  • CAS No. 1227572-43-1

  • Cat. No. CS-W021510
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-methoxypyridine|CS-W021510

Structure of 1227572-43-1

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General Information

  • CAS No. 1227572-43-1
  • Cat. No. CS-W021510
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂NO
  • Molecular Weight 178.02
  • Synonym(s) None
  • SMILES COC1=CC(Cl)=CC(Cl)=N1

Description

2,4-Dichloro-6-methoxypyridine features a pyridine core functionalized with chlorine atoms at positions 2 and 4 and a methoxy group at position 6, delivering enhanced reactivity and stability. This electron-deficient heterocycle serves as a key intermediate in pharmaceutical synthesis, particularly for kinase inhibitors and agrochemicals. The ortho-chloro arrangement facilitates nucleophilic substitution under mild conditions, while the para-methoxy group improves solubility and metabolic resistance.

Application

2,4-Dichloro-6-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling selective functionalization via nucleophilic substitution at the C2 or C4 positions. The methoxy group enhances solubility and modulates electronic properties, while the dichloro substitution pattern provides orthogonal reactivity for sequential coupling reactions. This compound exhibits good bench stability and facilitates efficient synthesis of heterocyclic scaffolds relevant to agrochemical and pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.397
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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