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CS-W001157 4
Total: USD 88.00

2-Chloro-3-methoxy-5-(trifluoromethyl)pyridine

  • CAS No. 1227563-67-8

  • Cat. No. CS-0199638
  • Purity≥98%
  • MDL No.MFCD16610622

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-methoxy-5-(trifluoromethyl)pyridine|CS-0199638

Structure of 1227563-67-8

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General Information

  • CAS No. 1227563-67-8
  • Cat. No. CS-0199638
  • Purity ≥98%
  • MDL No. MFCD16610622
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClF₃NO
  • Molecular Weight 211.57
  • Synonym(s) None
  • SMILES COC1=C(Cl)N=CC(=C1)C(F)(F)F

Description

2-Chloro-3-methoxy-5-(trifluoromethyl)pyridine features a trifluoromethyl group enhancing electron deficiency and metabolic stability, while the methoxy substituent improves solubility and reactivity in cross-coupling. This pyridine scaffold serves as a robust building block for pharmaceutical intermediates and agrochemicals under standard conditions.

Application

2-Chloro-3-methoxy-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond and electron-deficient pyridine core. The methoxy and trifluoromethyl groups provide orthogonal functional handles for further derivatization, while the compound exhibits excellent bench stability and compatibility with standard synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.7624
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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