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6-Methoxy-2-methylpyridine-3-carboxylic acid

  • CAS No. 1227515-71-0

  • Cat. No. CS-0183609
  • Molecule weight167.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-2-methylpyridine-3-carboxylic acid|CS-0183609

Structure of 1227515-71-0

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General Information

  • CAS No. 1227515-71-0
  • Cat. No. CS-0183609
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) 6-Methoxy-2-Methylpyridin-3-carboxylic acid
  • SMILES CC1=NC(=CC=C1C(=O)O)OC

Description

6-Methoxy-2-methylpyridine-3-carboxylic acid features a pyridine core functionalized with methoxy, methyl, and carboxylic acid groups at strategic positions. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

6-Methoxy-2-methylpyridine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its orthogonal functionalization profile—combining a carboxylic acid for coupling reactions, a methoxy group for derivatization, and a methyl substituent at the 2-position—facilitates diverse synthetic transformations. The molecule exhibits good bench stability and is compatible with standard amide coupling, Suzuki-Miyaura, and Buchwald-Hartwig protocols, making it well-suited for API intermediate development and library synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.09682
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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