2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine

Name: 2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine
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CAS No. 1227499-99-1
Cat. No. CS-0130934
Molecule weight211.57
Purity≥97%
MDL No.MFCD16610624

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2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine|CS-0130934

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General Information

CAS No. 1227499-99-1
Cat. No. CS-0130934
Purity ≥97%
MDL No. MFCD16610624
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClF₃NO
Molecular Weight 211.57
Synonym(s) None
SMILES FC(C1=CN=C(Cl)C=C1OC)(F)F

Description

2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the methoxy substituent improves solubility and reactivity in cross-coupling processes. This pyridine scaffold serves as a key building block in agrochemical and pharmaceutical synthesis, offering robust performance under standard reaction conditions.

Application

2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond and electron-deficient pyridine core. The methoxy and trifluoromethyl groups provide orthogonal functional handles and enhanced metabolic stability, while the compound exhibits excellent bench stability and compatibility with standard purification methods.

Safety Information

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Computational Chemistry Data

TPSA 22.12
LogP 2.7624
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine

CAS No. 1227499-99-1

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