2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine

Name: 2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 1227499-99-1
Cat. No. CS-0130934
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine|CS-0130934

Structure of 1227499-99-1

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Description

2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the methoxy substituent improves solubility and reactivity in cross-coupling processes. This pyridine scaffold serves as a key building block in agrochemical and pharmaceutical synthesis, offering robust performance under standard reaction conditions.

Application

2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond and electron-deficient pyridine core. The methoxy and trifluoromethyl groups provide orthogonal functional handles and enhanced metabolic stability, while the compound exhibits excellent bench stability and compatibility with standard purification methods.

General Information

CAS No. 1227499-99-1
Cat. No. CS-0130934
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClF₃NO
Molecular Weight 211.57
Synonym(s) None
SMILES FC(C1=CN=C(Cl)C=C1OC)(F)F

Computational Chemistry Data

TPSA 22.12
LogP 2.7624
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-methoxy-5-(trifluoromethyl)pyridine

CAS No. 1227499-99-1

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