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CS-W001157 4
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5-Iodo-4-methoxypyridin-2-amine

  • CAS No. 1226879-32-8

  • Cat. No. CS-0103371
  • Purity≥98%
  • MDL No.MFCD28669280

*For research and further manufacturing use only, not for direct human use.

5-Iodo-4-methoxypyridin-2-amine|CS-0103371

Structure of 1226879-32-8

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General Information

  • CAS No. 1226879-32-8
  • Cat. No. CS-0103371
  • Purity ≥98%
  • MDL No. MFCD28669280
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇IN₂O
  • Molecular Weight 250.04
  • Synonym(s) 5-Iodo-4-methoxy-pyridin-2-ylamine
  • SMILES NC1=NC=C(C(OC)=C1)I

Description

5-Iodo-4-methoxypyridin-2-amine features a pyridine core functionalized with iodine at C5 and a methoxy group at C4, enabling efficient cross-coupling reactions. The ortho-amino substituent provides a handle for further derivatization, while the electron-withdrawing iodide facilitates palladium-catalyzed transformations. This compound serves as a versatile scaffold in medicinal chemistry and materials synthesis.

Application

5-Iodo-4-methoxypyridin-2-amine serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to functionalized pyridine scaffolds. The iodide group facilitates reliable C–C and C–N bond formation under standard conditions, while the methoxy and amino functionalities provide orthogonal reactivity and enhanced solubility. This compound exhibits bench stability and is compatible with diverse reaction environments, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.277
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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