2-Chloro-5-iodo-4-methoxypyridine

Name: 2-Chloro-5-iodo-4-methoxypyridine
Brand: ChemScene
Availability: InStock
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CAS No. 1226878-98-3
Cat. No. CS-0150448
Molecule weight269.47
Purity≥97%
MDL No.MFCD18415711

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-iodo-4-methoxypyridine|CS-0150448

Structure of 1226878-98-3

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General Information

CAS No. 1226878-98-3
Cat. No. CS-0150448
Purity ≥97%
MDL No. MFCD18415711
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClINO
Molecular Weight 269.47
Synonym(s) None
SMILES COC1=CC(=NC=C1I)Cl

Description

2-Chloro-5-iodo-4-methoxypyridine features a pyridine core functionalized with chlorine, iodine, and methoxy groups at distinct positions, enabling selective cross-coupling reactions. The electron-deficient aromatic ring pairs effectively with palladium catalysts, while the methoxy group enhances solubility and stabilizes intermediates under standard conditions. This compound serves as a key building block in the synthesis of advanced pharmaceuticals and agrochemicals.

Application

2-Chloro-5-iodo-4-methoxypyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of substituted pyridine scaffolds. The chloro and iodo groups provide orthogonal reactivity for Pd-catalyzed coupling reactions, while the methoxy group offers moderate electron-donating character and stability under standard reaction conditions. Its bench-stable nature and compatibility with diverse functional groups facilitate reliable use in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 22.12
LogP 2.3482
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-iodo-4-methoxypyridine

CAS No. 1226878-98-3

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