4-Bromo-2-(difluoromethyl)-6-methylpyridine

Name: 4-Bromo-2-(difluoromethyl)-6-methylpyridine
Brand: ChemScene
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CAS No. 1226800-12-9
Cat. No. CS-0135393
Purity≥95%
MDL No.MFCD25477799

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-2-(difluoromethyl)-6-methylpyridine|CS-0135393

Structure of 1226800-12-9

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General Information

CAS No. 1226800-12-9
Cat. No. CS-0135393
Purity ≥95%
MDL No. MFCD25477799
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆BrF₂N
Molecular Weight 222.03
Synonym(s) None
SMILES CC1=CC(Br)=CC(C(F)F)=N1

Description

4-Bromo-2-(difluoromethyl)-6-methylpyridine features a trifunctional pyridine core with distinct reactivity profiles. The bromine at C4 enables palladium-catalyzed cross-coupling, while the difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties. The methyl substituent at C6 provides steric control and improves solubility in organic media. This compound serves as a key intermediate in medicinal chemistry for targeted heterocycle synthesis.

Application

4-Bromo-2-(difluoromethyl)-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen functionality. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the methyl substituent provides steric and electronic tuning. This compound exhibits excellent bench stability and facilitates efficient synthesis of complex heterocyclic scaffolds via standard coupling protocols.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 3.09012
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-2-(difluoromethyl)-6-methylpyridine

CAS No. 1226800-12-9

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