2,3-Dimethylpyridin-4-amine

Name: 2,3-Dimethylpyridin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 122475-57-4
Cat. No. CS-W002154
Purity≥97%
MDL No.MFCD00030819

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 122475-57-4

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General Information

CAS No. 122475-57-4
Cat. No. CS-W002154
Purity ≥97%
MDL No. MFCD00030819
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀N₂
Molecular Weight 122.17
Synonym(s) None
SMILES NC1=C(C)C(C)=NC=C1

Description

2,3-Dimethylpyridin-4-amine features a pyridine core with methyl groups at positions 2 and 3, enhancing electron density at the nitrogen lone pair. This configuration imparts improved solubility and stability in polar solvents, facilitating use in transition metal catalysis and pharmaceutical synthesis. The para-amino substitution enables direct coupling reactions under mild conditions.

Application

2,3-Dimethylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its pyridine core exhibits favorable solubility and bench stability, while the ortho-methyl groups enhance metabolic resistance and modulate electronic properties. The primary amine functions as a direct handle for derivatization, facilitating rapid access to diverse analogs in lead optimization campaigns.

Synthesis

Route1
- 37699-43-7
- ~96%
- In-stock
  
  122475-57-4
References
- Tanga; Bupp; Tochimoto Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 717 - 727
Route2
- 22710-07-2
- ~%
- In-stock
  
  122475-57-4
References
- Tanga; Bupp; Tochimoto Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 717 - 727

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2671
Class : 6.1	Packing Group : Ⅱ
Hazard Statements : H301-H311-H315-H319-H332-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.28064
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,3-Dimethylpyridin-4-amine

CAS No. 122475-57-4

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