Methyl 6-chloro-4-methylnicotinate

Name: Methyl 6-chloro-4-methylnicotinate
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CAS No. 1224464-97-4
Cat. No. CS-0145306
Purity≥98%
MDL No.MFCD18258050

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Methyl 6-chloro-4-methylnicotinate|CS-0145306

Structure of 1224464-97-4

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General Information

CAS No. 1224464-97-4
Cat. No. CS-0145306
Purity ≥98%
MDL No. MFCD18258050
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₂
Molecular Weight 185.61
Synonym(s) Methyl 6-chloro-4-Methylpyridine-3-carboxylate
SMILES O=C(C1=C(C)C=C(Cl)N=C1)OC

Description

Methyl 6-chloro-4-methylnicotinate is a halogenated pyridine derivative featuring a methyl ester group at the nicotinic acid core. This compound bears a chloro substituent at the 6-position and a methyl group at the 4-position, conferring enhanced electron-withdrawing character and improved metabolic stability. The ester functionality enables direct incorporation into synthetic sequences without additional activation. Designed for use in medicinal chemistry and agrochemical research, it serves as a key building block for bioactive heterocycles.

Application

Methyl 6-chloro-4-methylnicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted nicotinates via palladium-catalyzed cross-coupling and nucleophilic substitution. The ortho-chloro group facilitates selective functionalization, while the methyl ester and methylpyridine framework provide compatibility with standard synthetic transformations. Bench-stable and readily purified, it functions effectively in the construction of heterocyclic scaffolds relevant to API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 39.19
LogP 1.83002
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 6-chloro-4-methylnicotinate

CAS No. 1224464-97-4

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