N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine

Name: N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1223105-51-8
Cat. No. CS-0439186
Purity≥97%
MDL No.MFCD22989428

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine|CS-0439186

Structure of 1223105-51-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1223105-51-8
Cat. No. CS-0439186
Purity ≥97%
MDL No. MFCD22989428
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₁F₂NO₄
Molecular Weight 437.44
Synonym(s) (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoic acid
SMILES FC(C=CC=C1F)=C1C[C@](C(O)=O)(C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine is a sterically hindered, electron-deficient amino acid derivative designed for peptide synthesis. The α-methyl group confers conformational rigidity, while the ortho-fluorine substituents enhance metabolic stability and modulate electronic properties. This residue integrates seamlessly into challenging sequences, offering improved solubility and resistance to enzymatic degradation under standard coupling conditions.

Application

N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine serves as a valuable building block for the synthesis of bioactive peptides and peptidomimetics. The ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, while the α-methyl group confers conformational rigidity and resistance to proteolytic degradation. The Fmoc protecting group enables efficient solid-phase peptide synthesis with straightforward deprotection under mild basic conditions. This derivative facilitates the incorporation of sterically constrained, electron-deficient aromatic side chains into target scaffolds with high reliability and reproducibility.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 75.63
LogP 4.8893
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

1223105-51-8 sigma1223105-51-8 manufacturer1223105-51-8 price1223105-51-8 structure1223105-51-8 SDSbuy 1223105-51-81223105-51-8 supplier1223105-51-8 uses1223105-51-8 molecular weightprice of 1223105-51-81223105-51-8 chemical name formula of 1223105-51-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine

CAS No. 1223105-51-8

Recommended Products