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CS-W001157 4
Total: USD 88.00

2,2'-(Piperazine-1,4-diyl)diethanol

  • CAS No. 122-96-3

  • Cat. No. CS-W017493
  • Purity≥98%
  • MDL No.MFCD00006157

*For research and further manufacturing use only, not for direct human use.

2,2'-(Piperazine-1,4-diyl)diethanol|CS-W017493

Structure of 122-96-3

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General Information

  • CAS No. 122-96-3
  • Cat. No. CS-W017493
  • Purity ≥98%
  • MDL No. MFCD00006157
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂O₂
  • Molecular Weight 174.24
  • Synonym(s) None
  • SMILES OCCN1CCN(CCO)CC1

Description

t-Boc-N-amido-PEG5-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Synthesis

  • Route1
    • null|null
      111-42-2
    • ~79%
    • In-stock
      2,2'-(Piperazine-1,4-diyl)diethanol|CS-W017493
      122-96-3

    References

    • US2012/108816 A1, ; Page/Page column 6 ;
  • Route2
    • 3-(2-Hydroxyethyl)oxazolidin-2-one|CS-0120019
      3356-88-5
    • ~%
    • In-stock
      2,2'-(Piperazine-1,4-diyl)diethanol|CS-W017493
      122-96-3

    References

    • WO2014/39551 A1, ; Paragraph 32 ;
  • Route3
    • null|null
      141-43-5
    • ~26%
    • 1-(2-Hydroxyethyl)piperazine Dasatinib Impurity|CS-0228904
      103-76-4
    • In-stock
      2,2'-(Piperazine-1,4-diyl)diethanol|CS-W017493
      122-96-3

    References

    • European Journal of Organic Chemistry, , # 34 p. 6752 - 6759

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H318
Precautionary Statements : P280

Quality Control

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Computational Chemistry Data

  • TPSA   46.94
  • LogP   -1.4114
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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