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Boc-N-Amido-PEG4-propargyl

  • CAS No. 1219810-90-8

  • Cat. No. CS-0114862
  • Purity≥96%
  • MDL No.MFCD30182022

*For research and further manufacturing use only, not for direct human use.

Boc-N-Amido-PEG4-propargyl|CS-0114862

Structure of 1219810-90-8

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General Information

  • CAS No. 1219810-90-8
  • Cat. No. CS-0114862
  • Purity ≥96%
  • MDL No. MFCD30182022
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₉NO₆
  • Molecular Weight 331.40
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCNC(OC(C)(C)C)=O

Description

Boc-N-Amido-PEG4-propargyl features a terminal alkyne for copper-catalyzed click chemistry and a Boc-protected amine for controlled functionalization. This PEG4 spacer provides enhanced solubility and stability, enabling efficient conjugation in bioconjugation workflows under standard conditions.

Application

Boc-N-Amido-PEG4-propargyl serves as a versatile bifunctional linker for bioconjugation and solid-phase synthesis. The propargyl group enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Boc-protected amine facilitates orthogonal handling and selective deprotection. This reagent exhibits excellent stability under standard bench conditions, tolerates diverse functional groups, and simplifies purification due to its polarity profile—ideal for constructing PEGylated probes, peptide conjugates, and modular scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   75.25
  • LogP   1.2107
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   13

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