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CS-W001157 4
Total: USD 88.00

4-Bromo-5-fluoro-2-iodoaniline

  • CAS No. 1219741-79-3

  • Cat. No. CS-0050981
  • Purity≥95%
  • MDL No.MFCD26386356

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-fluoro-2-iodoaniline|CS-0050981

Structure of 1219741-79-3

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General Information

  • CAS No. 1219741-79-3
  • Cat. No. CS-0050981
  • Purity ≥95%
  • MDL No. MFCD26386356
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrFIN
  • Molecular Weight 315.91
  • Synonym(s) 4-bromo-5-fluoro-2-iodo-phenylamine
  • SMILES NC1=CC(F)=C(Br)C=C1I

Description

4-Bromo-5-fluoro-2-iodoaniline features three halogen substituents on an aromatic ring, enabling sequential cross-coupling reactions in medicinal chemistry. The strategic placement of bromo, fluoro, and iodo groups supports modular synthesis of complex heterocycles. This compound exhibits bench-stable handling characteristics and delivers high functional group tolerance under standard coupling conditions.

Application

4-Bromo-5-fluoro-2-iodoaniline serves as a versatile trihalogenated aniline building block for the synthesis of complex heterocycles and pharmaceutical intermediates. Its orthogonal halogen reactivity enables sequential cross-coupling reactions under palladium catalysis, facilitating the construction of biaryl and fused ring systems. The molecule exhibits good bench stability and is amenable to standard purification techniques, making it well-suited for scalable synthetic workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.775
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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