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CS-W001157 4
Total: USD 88.00

(2-Bromo-4-fluorophenyl)boronic acid

  • CAS No. 1217501-12-6

  • Cat. No. CS-0137640
  • Purity≥98%
  • MDL No.MFCD13195647

*For research and further manufacturing use only, not for direct human use.

(2-Bromo-4-fluorophenyl)boronic acid|CS-0137640

Structure of 1217501-12-6

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General Information

  • CAS No. 1217501-12-6
  • Cat. No. CS-0137640
  • Purity ≥98%
  • MDL No. MFCD13195647
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BBrFO₂
  • Molecular Weight 218.82
  • Synonym(s) 2-Bromo-4-fluorophenylboronic acid
  • SMILES OB(C1=CC=C(F)C=C1Br)O

Description

This boronic acid features a strategically positioned bromo and fluoro substituent on the phenyl ring, enabling selective cross-coupling reactions. The electron-deficient aryl moiety enhances reactivity in palladium-catalyzed transformations, while the boronic acid group offers reliable coupling efficiency under standard conditions.

Application

(2-Bromo-4-fluorophenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation with aryl halides and triflates. Its dual halogen functionality provides orthogonal reactivity for sequential transformations. The boronic acid moiety offers excellent stability under ambient conditions, facilitates straightforward purification, and exhibits broad functional group tolerance, making it well-suited for the synthesis of complex pharmaceutical intermediates and biaryl scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.268
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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