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CS-W001157 4
Total: USD 88.00

(2-Bromo-5-fluorophenyl)boronic acid

  • CAS No. 959996-48-6

  • Cat. No. CS-0047538
  • Purity≥98%
  • MDL No.MFCD08690232

*For research and further manufacturing use only, not for direct human use.

(2-Bromo-5-fluorophenyl)boronic acid|CS-0047538

Structure of 959996-48-6

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General Information

  • CAS No. 959996-48-6
  • Cat. No. CS-0047538
  • Purity ≥98%
  • MDL No. MFCD08690232
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BBrFO₂
  • Molecular Weight 218.82
  • Synonym(s) 2-Bromo-5-fluorophenylboronic acid
  • SMILES OB(C1=CC(F)=CC=C1Br)O

Description

(2-Bromo-5-fluorophenyl)boronic acid features a strategically positioned boronic acid group flanked by bromine and fluorine substituents, enabling selective cross-coupling reactions. This electron-deficient aryl boronate integrates efficiently into Suzuki-Miyaura transformations under mild conditions, offering high functional group tolerance and reliable coupling yields.

Application

(2-Bromo-5-fluorophenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its compatibility with diverse functional groups and robust bench stability make it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.268
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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