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Ethyl (E)-2-amino-2-(hydroxyimino)acetate

  • CAS No. 1217428-98-2

  • Cat. No. CS-0166894
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl (E)-2-amino-2-(hydroxyimino)acetate|CS-0166894

Structure of 1217428-98-2

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General Information

  • CAS No. 1217428-98-2
  • Cat. No. CS-0166894
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈N₂O₃
  • Molecular Weight 132.12
  • Synonym(s) Acetic acid, 2-amino-2-(hydroxyimino)-, ethyl ester, (2E)-
  • SMILES O=C(OCC)/C(N)=N\O

Description

Ethyl (E)-2-amino-2-(hydroxyimino)acetate features a stable E-configured oxime moiety that enables selective coupling reactions in peptide synthesis. This bench-stable derivative integrates readily into amide bond formation protocols, offering enhanced reactivity without requiring harsh activation conditions.

Application

Ethyl (E)-2-amino-2-(hydroxyimino)acetate serves as a versatile building block for heterocyclic synthesis, particularly in the construction of oxadiazole and triazole scaffolds. Its stable E-configured hydroxyimino group enables selective coupling reactions under mild conditions, while the amino and ester functionalities offer orthogonal reactivity for downstream functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS06
Signal Word : Danger
UN#: 2926
Class : 4.1,6.1
Packing Group : Ⅲ
Hazard Statements : H228-H301+H311+H331-H315-H319
Precautionary Statements : P210-P240-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   84.91
  • LogP   -0.7041
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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