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CS-W001157 4
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Amino-hydroxyimino-acetic acid ethyl ester

  • CAS No. 10489-74-4

  • Cat. No. CS-0038067
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Amino-hydroxyimino-acetic acid ethyl ester|CS-0038067

Structure of 10489-74-4

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General Information

  • CAS No. 10489-74-4
  • Cat. No. CS-0038067
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈N₂O₃
  • Molecular Weight 132.12
  • Synonym(s) Ethyl-2-Oximinooxamate
  • SMILES CCOC(=O)C(=N)NO

Description

Amino-hydroxyimino-acetic acid ethyl ester delivers a reactive imino ether functionality for efficient conjugation workflows. This bench-stable derivative integrates readily into peptide synthesis and bioconjugation protocols, offering enhanced solubility and predictable reactivity under standard conditions.

Application

Amino-hydroxyimino-acetic acid ethyl ester serves as a versatile building block for the synthesis of hydroxylated imine-containing scaffolds, enabling efficient access to functionalized heterocycles and peptide-like motifs. Its stability under standard bench conditions and compatibility with common protecting group strategies facilitate straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • PONIARD PHARMACEUTICALS, INC. Patent: WO2009/139834 A1, 2009 ; Location in patent: Page/Page column 151 ;
  • Route2
    • In-stock
      Ethyl carbonocyanidate|CS-0022374
      623-49-4
    • ~76%
    • In-stock
      Amino-hydroxyimino-acetic acid ethyl ester|CS-0038067
      10489-74-4
    • null|null
      25475-06-3

    References

    • Tetrahedron, , vol. 48, # 30 p. 6335 - 6360

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   82.41
  • LogP   -0.49443
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   1

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