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5-Fluoro-1H-indol-6-amine

  • CAS No. 121716-63-0

  • Cat. No. CS-0155537
  • Purity≥98%
  • MDL No.MFCD12924060

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-indol-6-amine|CS-0155537

Structure of 121716-63-0

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General Information

  • CAS No. 121716-63-0
  • Cat. No. CS-0155537
  • Purity ≥98%
  • MDL No. MFCD12924060
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FN₂
  • Molecular Weight 150.15
  • Synonym(s) 1H-Indol-6-amine,5-fluoro-(9CI)
  • SMILES C1=CNC2=CC(=C(C=C12)F)N

Description

5-Fluoro-1H-indol-6-amine is a fluorinated indole derivative featuring a primary amine at the 6-position, enabling direct conjugation in synthetic transformations. This electron-deficient scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor and CNS-targeted compound libraries. The fluorine substituent enhances metabolic stability and modulates electronic properties for improved target engagement.

Application

5-Fluoro-1H-indol-6-amine serves as a valuable building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its fluorinated indole core enables enhanced metabolic stability and modulated electronic properties, while the primary amine facilitates straightforward derivatization via amidation, acylation, or coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it a practical choice for medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.81
  • LogP   1.8892
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   0

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