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CS-W001157 4
Total: USD 88.00

6-Fluoro-1H-indol-4-amine

  • CAS No. 885518-25-2

  • Cat. No. CS-0043987
  • Purity≥97%
  • MDL No.MFCD07357294

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-1H-indol-4-amine|CS-0043987

Structure of 885518-25-2

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General Information

  • CAS No. 885518-25-2
  • Cat. No. CS-0043987
  • Purity ≥97%
  • MDL No. MFCD07357294
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FN₂
  • Molecular Weight 150.15
  • Synonym(s) 4-Amino-6-fluoro-1H-indole
  • SMILES NC1=CC(F)=CC2=C1C=CN2

Description

6-Fluoro-1H-indol-4-amine features a fluorinated indole core with a primary amine at the 4-position, enabling direct incorporation into bioactive scaffolds. The electron-withdrawing fluorine substituent enhances metabolic stability and modulates electronic properties for targeted ligand design. This bench-stable derivative serves as a key intermediate in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

6-Fluoro-1H-indol-4-amine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling direct incorporation into pharmaceutical scaffolds via standard coupling reactions. Its fluorinated indole core exhibits enhanced metabolic stability and favorable electronic properties, while the primary amine facilitates facile derivatization. The compound demonstrates good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthetic approaches in medicinal chemistry.

Synthesis

  • Route1
    • null|null
      1389326-30-0
    • ~%
    • In-stock
      6-Fluoro-1H-indol-4-amine|CS-0043987
      885518-25-2

    References

    • WO2012/97744 A1, ; Page/Page column 74-75# ; WO 2012/097744 A1
  • Route2
    • null|null
      102735-88-6
    • ~%
    • In-stock
      6-Fluoro-1H-indol-4-amine|CS-0043987
      885518-25-2

    References

    • WO2012/97744 A1, ; WO 2012/097744 A1
  • Route3

    References

    • WO2012/97744 A1, ; WO 2012/097744 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.81
  • LogP   1.8892
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   0

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