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Structure of 121669-70-3
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tert-Butyl 4-iodo-1H-pyrazole-1-carboxylate features a bench-stable pyrazole core functionalized with a reactive iodide at the 4-position, enabling direct coupling in cross-coupling reactions. The tert-butyl ester group offers enhanced solubility and stability during synthetic manipulations, facilitating efficient incorporation into complex molecular architectures.
tert-Butyl 4-iodo-1H-pyrazole-1-carboxylate serves as a versatile building block for the synthesis of functionalized pyrazole scaffolds. The iodine substituent enables efficient palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Sonogashira couplings, facilitating rapid diversification. The tert-butyl carbamate group provides excellent stability under basic conditions and can be readily removed via acidolysis to yield the free amine. This reagent exhibits high bench stability, ease of purification, and broad compatibility with common functional groups, making it ideal for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: