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CS-W001157 4
Total: USD 88.00

(3-Chloro-5-hydroxyphenyl)boronic acid

  • CAS No. 1214900-52-3

  • Cat. No. CS-0043765
  • Purity≥98%
  • MDL No.MFCD15143456

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-5-hydroxyphenyl)boronic acid|CS-0043765

Structure of 1214900-52-3

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General Information

  • CAS No. 1214900-52-3
  • Cat. No. CS-0043765
  • Purity ≥98%
  • MDL No. MFCD15143456
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BClO₃
  • Molecular Weight 172.37
  • Synonym(s) 3-Chloro-5-hydroxyphenylboronic acid
  • SMILES OC1=CC(Cl)=CC(B(O)O)=C1

Description

This boronate moiety features a chlorinated phenolic scaffold, enabling direct functionalization in Suzuki-Miyaura couplings. The hydroxyl group enhances solubility and provides a handle for derivatization, while the electron-deficient aryl ring facilitates palladium-catalyzed cross-coupling under standard conditions.

Application

(3-Chloro-5-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling the efficient construction of biaryl scaffolds. The ortho-chloro and phenolic hydroxyl groups provide orthogonal reactivity for downstream functionalization, while the boronic acid moiety offers excellent bench stability and compatibility with aqueous workups. Its predictable coupling behavior and mild reaction conditions make it a reliable choice for synthesizing complex aromatic architectures in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.2746
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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