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CS-W001157 4
Total: USD 88.00

5-Bromo-6-hydroxypicolinic acid

  • CAS No. 1214385-51-9

  • Cat. No. CS-W006650
  • Purity≥96%
  • MDL No.MFCD13185807

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-hydroxypicolinic acid|CS-W006650

Structure of 1214385-51-9

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General Information

  • CAS No. 1214385-51-9
  • Cat. No. CS-W006650
  • Purity ≥96%
  • MDL No. MFCD13185807
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNO₃
  • Molecular Weight 218.01
  • Synonym(s) None
  • SMILES O=C(O)C1=NC(O)=C(Br)C=C1

Description

5-Bromo-6-hydroxypicolinic acid features a bromine substituent at the 5-position and a hydroxyl group at the 6-position of the picolinic acid scaffold. This combination imparts enhanced polarity and hydrogen-bonding capacity, facilitating solubility in polar solvents and enabling robust conjugation in synthetic applications. The molecule serves as a key building block for bioactive heterocycles and metal-chelating ligands in catalysis and medicinal chemistry.

Application

5-Bromo-6-hydroxypicolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its dual functionality—bromine at C5 and hydroxyl at C6—enables selective cross-coupling reactions and regiocontrolled derivatization. The molecule exhibits good bench stability, facilitates straightforward purification via recrystallization, and functions effectively in Pd-catalyzed transformations, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   1.2479
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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