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CS-W001157 4
Total: USD 88.00

2-Bromo-6-(difluoromethoxy)pyridine

  • CAS No. 1214345-40-0

  • Cat. No. CS-W007246
  • Molecule weight224.00
  • Purity≥97%
  • MDL No.MFCD13185843

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-(difluoromethoxy)pyridine|CS-W007246

Structure of 1214345-40-0

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General Information

  • CAS No. 1214345-40-0
  • Cat. No. CS-W007246
  • Purity ≥97%
  • MDL No. MFCD13185843
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂NO
  • Molecular Weight 224.00
  • Synonym(s) None
  • SMILES FC(F)OC1=CC=CC(Br)=N1

Description

2-Bromo-6-(difluoromethoxy)pyridine features a strategically positioned difluoromethoxy group that enhances electron withdrawal and metabolic stability. This fluorinated pyridine scaffold serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules via cross-coupling reactions. The molecule exhibits excellent bench-stability and compatibility with standard reaction conditions.

Application

2-Bromo-6-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and electron-deficient pyridine core. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, making this scaffold valuable for constructing bioactive heterocycles. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.4455
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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