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CS-W001157 4
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4-Bromo-2-(difluoromethoxy)pyridine

  • CAS No. 832735-56-5

  • Cat. No. CS-W019083
  • Purity≥95%
  • MDL No.MFCD14584703

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-(difluoromethoxy)pyridine|CS-W019083

Structure of 832735-56-5

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General Information

  • CAS No. 832735-56-5
  • Cat. No. CS-W019083
  • Purity ≥95%
  • MDL No. MFCD14584703
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂NO
  • Molecular Weight 224.00
  • Synonym(s) None
  • SMILES FC(F)OC1=NC=CC(Br)=C1

Description

4-Bromo-2-(difluoromethoxy)pyridine features a strategically positioned difluoromethoxy group that enhances metabolic stability and modulates electronic properties. This electron-withdrawing substituent improves binding affinity in target-directed synthesis, while the bromine facilitates downstream cross-coupling reactions. The compound exhibits excellent bench stability and solubility in common organic solvents, enabling seamless integration into multi-step synthetic sequences.

Application

4-Bromo-2-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromine handle and compatible difluoromethoxy group. The molecule exhibits excellent bench stability and facilitates the construction of complex heterocyclic scaffolds relevant to pharmaceutical development.

Synthesis

  • Route1

    References

    • AstraZeneca AB Patent: US2010/125087 A1, 2010 ; Location in patent: Page/Page column 21 ; US 20100125087 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.4455
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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