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Ethyl 5-bromo-6-chloropicolinate

  • CAS No. 1214337-57-1

  • Cat. No. CS-0151678
  • Purity≥97%
  • MDL No.MFCD14698310

*For research and further manufacturing use only, not for direct human use.

Ethyl 5-bromo-6-chloropicolinate|CS-0151678

Structure of 1214337-57-1

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General Information

  • CAS No. 1214337-57-1
  • Cat. No. CS-0151678
  • Purity ≥97%
  • MDL No. MFCD14698310
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrClNO₂
  • Molecular Weight 264.50
  • Synonym(s) 2-Pyridinecarboxylic acid, 5-bromo-6-chloro-, ethyl ester
  • SMILES CCOC(=O)C1=NC(=C(C=C1)Br)Cl

Description

Ethyl 5-bromo-6-chloropicolinate features a highly functionalized picolinate core with bromo and chloro substituents at the 5- and 6-positions, respectively. This electron-deficient heterocycle enables efficient cross-coupling reactions in late-stage diversification. The ethyl ester group provides enhanced solubility and stability under standard reaction conditions.

Application

Ethyl 5-bromo-6-chloropicolinate serves as a versatile building block for the synthesis of substituted pyridine derivatives. Its orthogonal halogenation pattern enables sequential cross-coupling reactions, facilitating the construction of complex heterocyclic scaffolds. The ester functionality offers compatibility with standard transformations, while the molecule exhibits excellent bench stability and ease of purification—key attributes for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.6742
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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