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CS-W001157 4
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Methyl 6-bromo-3-fluoropicolinate

  • CAS No. 1214332-47-4

  • Cat. No. CS-0109810
  • Purity≥96%
  • MDL No.MFCD14698123

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromo-3-fluoropicolinate|CS-0109810

Structure of 1214332-47-4

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General Information

  • CAS No. 1214332-47-4
  • Cat. No. CS-0109810
  • Purity ≥96%
  • MDL No. MFCD14698123
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrFNO₂
  • Molecular Weight 234.02
  • Synonym(s) Methyl 6-broMo-3-fluoropyridine-2-carboxylate
  • SMILES O=C(C1=NC(Br)=CC=C1F)OC

Description

Methyl 6-bromo-3-fluoropicolinate is a fluorinated, brominated pyridine derivative featuring complementary electrophilic handles at the 3- and 6-positions. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key building block for bioactive molecule synthesis.

Application

Methyl 6-bromo-3-fluoropicolinate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties in pharmaceutical scaffolds. This compound exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.7698
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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