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(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride

  • CAS No. 1212327-95-1

  • Cat. No. CS-0053111
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride|CS-0053111

Structure of 1212327-95-1

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General Information

  • CAS No. 1212327-95-1
  • Cat. No. CS-0053111
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClN₂O₂
  • Molecular Weight 178.62
  • Synonym(s) (R)-Hexahydro-oxazolo[3,4-a]-pyrazin-3-one hydrochloride
  • SMILES O=C1OC[C@H]2CNCCN12.Cl

Description

(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride features a rigid, electron-deficient heterocyclic core with defined stereochemistry at the chiral center. This bench-stable compound integrates readily into medicinal chemistry campaigns requiring constrained, polar scaffolds for target engagement in kinase and GPCR pathways.

Application

(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds. Its well-defined stereochemistry and functional group tolerance facilitate efficient derivatization in standard coupling and cyclization reactions. The hydrochloride salt enhances bench stability and solubility, simplifying handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   -0.1678
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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