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Hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one hydrochloride

  • CAS No. 1020349-31-8

  • Cat. No. CS-0098238
  • Purity≥97%
  • MDL No.MFCD09878828

*For research and further manufacturing use only, not for direct human use.

Hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one hydrochloride|CS-0098238

Structure of 1020349-31-8

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General Information

  • CAS No. 1020349-31-8
  • Cat. No. CS-0098238
  • Purity ≥97%
  • MDL No. MFCD09878828
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClN₂O₂
  • Molecular Weight 178.62
  • Synonym(s) Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride
  • SMILES O=C1OCC2CNCCN21.Cl

Description

Hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one hydrochloride is a bench-stable heterocyclic scaffold featuring a fused oxazolo-pyrazine core. This crystalline salt delivers enhanced solubility and handling convenience in synthetic workflows. The protonated nitrogen system enables efficient incorporation into bioactive molecules and serves as a key building block for medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors.

Application

Hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one hydrochloride serves as a stable, bench-ready heterocyclic building block for medicinal chemistry campaigns. Its fused oxazolopyrazine core enables efficient functionalization at multiple positions and exhibits favorable solubility and crystallinity. The hydrochloride salt enhances stability and facilitates purification, making it well-suited for use in standard coupling reactions, reductive amination protocols, and the construction of complex nitrogen-containing scaffolds relevant to drug discovery pipelines.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   -0.1678
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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