tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Name: tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
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CAS No. 1212182-03-0
Cat. No. CS-0079202
Purity≥97%
MDL No.MFCD09608025

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate|CS-0079202

Structure of 1212182-03-0

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General Information

CAS No. 1212182-03-0
Cat. No. CS-0079202
Purity ≥97%
MDL No. MFCD09608025
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₃
Molecular Weight 215.29
Synonym(s) (R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
SMILES O=C(N1C[C@@H](CCO)CC1)OC(C)(C)C

Description

tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate features a chiral pyrrolidine core with a pendant hydroxyl group, enabling selective functionalization in asymmetric synthesis. The tert-butyl ester offers stability and ease of removal under mild acidic conditions. This scaffold integrates readily into bioactive molecule design, particularly in medicinal chemistry campaigns targeting CNS modulators and enzyme inhibitors.

Application

tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate serves as a chiral building block for the synthesis of bioactive heterocycles and medicinal intermediates. The pyrrolidine core provides a rigid, stereodefined scaffold with orthogonal functionality: the tert-butoxycarbonyl (Boc) group enables selective deprotection under mild acidic conditions, while the pendant hydroxyl moiety facilitates derivatization via etherification or esterification. This combination supports efficient route design in peptide-like compound development and offers bench-stable handling with good solubility in common organic solvents.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 49.77
LogP 1.6258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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tert-Butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

CAS No. 1212182-03-0

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