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CS-W001157 4
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6-(Difluoromethoxy)nicotinaldehyde

  • CAS No. 1211577-99-9

  • Cat. No. CS-0043758
  • Purity≥98%
  • MDL No.MFCD18261899

*For research and further manufacturing use only, not for direct human use.

6-(Difluoromethoxy)nicotinaldehyde|CS-0043758

Structure of 1211577-99-9

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General Information

  • CAS No. 1211577-99-9
  • Cat. No. CS-0043758
  • Purity ≥98%
  • MDL No. MFCD18261899
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight 173.12
  • Synonym(s) None
  • SMILES O=CC1=CN=C(C=C1)OC(F)F

Description

6-(Difluoromethoxy)nicotinaldehyde features a strategically positioned difluoromethoxy group that enhances electronic modulation and metabolic stability. This electron-deficient aldehyde integrates readily into synthetic scaffolds, enabling efficient access to bioactive heterocycles under mild conditions. The bench-stable, moisture-tolerant nature simplifies handling in process development workflows.

Application

6-(Difluoromethoxy)nicotinaldehyde serves as a versatile building block for heterocyclic synthesis, particularly in the development of bioactive molecules and pharmaceutical intermediates. Its pyridine aldehyde functionality enables efficient imine formation and condensation reactions, while the difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity. The compound exhibits good bench stability and compatibility with standard purification techniques, facilitating its use in multi-step synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.4955
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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