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CS-W001157 4
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2-(5-Bromopyrimidin-2-yl)propan-2-ol

  • CAS No. 1193244-89-1

  • Cat. No. CS-0036723
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(5-Bromopyrimidin-2-yl)propan-2-ol|CS-0036723

Structure of 1193244-89-1

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General Information

  • CAS No. 1193244-89-1
  • Cat. No. CS-0036723
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BrN₂O
  • Molecular Weight 217.06
  • Synonym(s) 5-Bromo-2-(1-hydroxy-1-methylethyl)pyrimidine
  • SMILES CC(C)(C1=NC=C(C=N1)Br)O

Description

This boronate moiety features a sterically hindered tertiary alcohol flanked by an electron-deficient pyrimidine ring, enabling robust coupling in cross-coupling protocols. The 5-bromopyrimidin-2-yl group provides a high-affinity handle for palladium-mediated transformations under standard conditions.

Application

2-(5-Bromopyrimidin-2-yl)propan-2-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the tertiary alcohol group offers stability and ease of purification. The molecule demonstrates excellent functional group tolerance and bench stability, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.4665
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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