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CS-W001157 4
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5-Fluoro-6-methoxypicolinic acid

  • CAS No. 1211534-53-0

  • Cat. No. CS-0163343
  • Molecule weight171.13
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-6-methoxypicolinic acid|CS-0163343

Structure of 1211534-53-0

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General Information

  • CAS No. 1211534-53-0
  • Cat. No. CS-0163343
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₃
  • Molecular Weight 171.13
  • Synonym(s) 5-fluoro-6-methoxypyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(OC)=C(F)C=C1

Description

5-Fluoro-6-methoxypicolinic acid features a strategically positioned fluorine and methoxy group on the picolinic acid scaffold, enhancing electron withdrawal and metabolic stability. This combination improves solubility and facilitates conjugation in bioactive molecule design. The compound serves as a key building block for pharmaceutical intermediates and functionalized heterocycles under standard conditions.

Application

5-Fluoro-6-methoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functional groups—fluorine at C5 and methoxy at C6—facilitate selective derivatization and modulate electronic properties. The carboxylic acid group supports direct coupling reactions, while the compound exhibits good bench stability and ease of purification, making it suitable for scalable synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.9275
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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