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Structure of 1211530-15-2
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4-Fluoro-5-methylpicolinic acid features a fluorinated pyridine core with a methyl group at the 5-position, enhancing electronic and steric properties. This configuration supports robust coupling efficiency in amide bond formation and facilitates integration into bioactive scaffolds requiring metabolic stability and targeted lipophilicity.
4-Fluoro-5-methylpicolinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluoro and methyl substituents provide enhanced metabolic stability and modulate electronic properties, facilitating efficient coupling reactions. The carboxylic acid group offers direct functionality for amide formation, esterification, or salt formation, supporting versatile downstream derivatization. This compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for routine synthetic applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: