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CS-W001157 4
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4-Fluoro-5-methylpicolinic acid

  • CAS No. 1211530-15-2

  • Cat. No. CS-0094255
  • Molecule weight155.13
  • Purity≥95%
  • MDL No.MFCD18257374

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-5-methylpicolinic acid|CS-0094255

Structure of 1211530-15-2

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General Information

  • CAS No. 1211530-15-2
  • Cat. No. CS-0094255
  • Purity ≥95%
  • MDL No. MFCD18257374
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 4-Fluoro-5-methyl-2-pyridinecarboxylic acid
  • SMILES O=C(C1=NC=C(C)C(F)=C1)O

Description

4-Fluoro-5-methylpicolinic acid features a fluorinated pyridine core with a methyl group at the 5-position, enhancing electronic and steric properties. This configuration supports robust coupling efficiency in amide bond formation and facilitates integration into bioactive scaffolds requiring metabolic stability and targeted lipophilicity.

Application

4-Fluoro-5-methylpicolinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluoro and methyl substituents provide enhanced metabolic stability and modulate electronic properties, facilitating efficient coupling reactions. The carboxylic acid group offers direct functionality for amide formation, esterification, or salt formation, supporting versatile downstream derivatization. This compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for routine synthetic applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.22732
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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