2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid

Name: 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1211526-53-2
Cat. No. CS-D0153
Purity≥97%
MDL No.MFCD17016194

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid|CS-D0153

Structure of 1211526-53-2

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General Information

CAS No. 1211526-53-2
Cat. No. CS-D0153
Purity ≥97%
MDL No. MFCD17016194
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₉NO₄
Molecular Weight 241.29
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(C(=O)O)C2

Description

This spirocyclic diacid derivative features a protected amine and carboxylic acid group, enabling direct incorporation into peptide synthesis. The tert-butoxycarbonyl moiety ensures stability during handling and reaction sequences. The rigid spirocyclic core provides defined stereochemistry and conformational control.

Application

2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles. The Boc-protected amine and carboxylic acid functionalities enable orthogonal functionalization, facilitating efficient peptide coupling and reductive amination workflows. Its rigid spirocyclic core enhances conformational control in medicinal chemistry applications, while the tert-butyl carbamate group offers excellent bench stability and ease of removal under mild acidic conditions.

Synthesis

Route1
- In-stock
  
  24424-99-5
- 1172252-57-1
- ~84%
- In-stock
  
  1211526-53-2
References
- Radchenko, Dmytro S.; Pavlenko, Sergiy O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.; Shishkina, Svitlana V.; Shishkin, Oleg V.; Komarov, Igor V. Journal of Organic Chemistry, 2010 , vol. 75, # 17 p. 5941 - 5952

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 1.7181
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid

CAS No. 1211526-53-2

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