Lot numbers can be found on the outside label of a product:
Boc-3-amino-2,2-dimethyl-propionic acid
-
CAS No. 180181-02-6
- Cat. No. CS-0139511
- Purity≥97%
- MDL No.MFCD09952625
*For research and further manufacturing use only, not for direct human use.
Structure of 180181-02-6
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 180181-02-6
- Cat. No. CS-0139511
- Purity ≥97%
- MDL No. MFCD09952625
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₉NO₄
- Molecular Weight 217.26
- Synonym(s) 3-((tert-Butoxycarbonyl)amino)-2,2-dimethylpropanoic acid
- SMILES O=C(O)C(C)(C)CNC(OC(C)(C)C)=O
Description
Boc-3-amino-2,2-dimethyl-propionic acid delivers a sterically hindered, bench-stable amino acid derivative ideal for peptide synthesis. The Boc group enables efficient protection of the primary amine, while the dimethyl-substituted propionic backbone enhances solubility and reduces racemization risk during coupling. This building block integrates seamlessly into complex sequences where steric bulk and stability are critical.
Application
Boc-3-amino-2,2-dimethyl-propionic acid serves as a stable, bench-ready building block for peptide synthesis and medicinal chemistry applications. The tert-butoxycarbonyl (Boc) group provides reliable protection of the primary amine, enabling orthogonal deprotection in standard protocols. Its sterically hindered dimethyl-substituted backbone enhances stability against racemization and facilitates efficient coupling reactions with minimal epimerization. This compound functions effectively in solid-phase and solution-phase syntheses, offering high purity and consistent performance in the construction of complex peptide architectures and heterocyclic scaffolds.
Synthesis
-
References
-
ZALICUS PHARMACEUTICALS LTD .; PAJOUHESH , Hassan; ZHU, Yongbao; ZHOU, Yuanxi; GRIMWOOD, Mike; SIMONSON, Eric Patent: WO2011/32291 A1, 2011 ; Location in patent: Page/Page column 47 ; WO 2011/032291 A1
-
-
Route2
-
195387-08-7 - ~97%
-
In-stock
180181-02-6
References
-
McCubbin, J. Adam; Maddess, Matthew L.; Lautens, Mark Organic Letters, 2006 , vol. 8, # 14 p. 2993 - 2996
-
-
Route3
-
In-stock
184357-44-6 - ~%
-
In-stock
180181-02-6
References
-
EP1548024 A1, ; Page/Page column 89-90 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302
|
|
|
Precautionary Statements : P264-P270-P301+P310-P330-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 75.63
- LogP 1.6219
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 3
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- Boc-3-amino-2,2-dimethyl-propionic acid sigmaBoc-3-amino-2,2-dimethyl-propionic acid manufacturerBoc-3-amino-2,2-dimethyl-propionic acid priceBoc-3-amino-2,2-dimethyl-propionic acid structureBoc-3-amino-2,2-dimethyl-propionic acid SDSbuy Boc-3-amino-2,2-dimethyl-propionic acidBoc-3-amino-2,2-dimethyl-propionic acid supplierBoc-3-amino-2,2-dimethyl-propionic acid usesBoc-3-amino-2,2-dimethyl-propionic acid molecular weightprice of Boc-3-amino-2,2-dimethyl-propionic acidBoc-3-amino-2,2-dimethyl-propionic acid chemical name formula of Boc-3-amino-2,2-dimethyl-propionic acid