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CS-W001157 4
Total: USD 88.00

5-(Difluoromethyl)-2-pyridinamine

  • CAS No. 1211523-68-0

  • Cat. No. CS-0029881
  • Purity≥98%
  • MDL No.MFCD18256527

*For research and further manufacturing use only, not for direct human use.

5-(Difluoromethyl)-2-pyridinamine|CS-0029881

Structure of 1211523-68-0

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General Information

  • CAS No. 1211523-68-0
  • Cat. No. CS-0029881
  • Purity ≥98%
  • MDL No. MFCD18256527
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂
  • Molecular Weight 144.12
  • Synonym(s) 5-(difluoromethyl)pyridin-2-amine
  • SMILES NC1=NC=C(C(F)F)C=C1

Description

5-(Difluoromethyl)-2-pyridinamine integrates a difluoromethyl group at the 5-position of a pyridinamine scaffold, delivering enhanced metabolic stability and improved lipophilicity. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient incorporation into bioactive molecules through direct functionalization or coupling reactions under mild conditions.

Application

5-(Difluoromethyl)-2-pyridinamine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its pyridinamine functionality facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions, while the difluoromethyl moiety enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6014
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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