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CS-W001157 4
Total: USD 88.00

6-Hydrazinylnicotinic acid

  • CAS No. 133081-24-0

  • Cat. No. CS-W003107
  • Purity≥95%
  • MDL No.MFCD03788692

*For research and further manufacturing use only, not for direct human use.

6-Hydrazinylnicotinic acid|CS-W003107

Structure of 133081-24-0

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General Information

  • CAS No. 133081-24-0
  • Cat. No. CS-W003107
  • Purity ≥95%
  • MDL No. MFCD03788692
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇N₃O₂
  • Molecular Weight 153.14
  • Synonym(s) HYDRALINK(TM) 6-HNA REAGENT
  • SMILES NNc1ccc(cn1)C(=O)O

Description

6-Hydrazinylnicotinic acid features a hydrazine group appended to the pyridine ring, enabling direct conjugation with carbonyl-containing compounds. This functionality facilitates rapid formation of hydrazone linkages under mild conditions, making it ideal for bioconjugation and probe synthesis. The molecule exhibits good solubility in aqueous and polar organic solvents, enhancing utility in solution-phase reactions.

Synthesis

  • Route1

    References

    • WO2010/96722 A1, ; Page/Page column 54-55 ; WO 2010/096722 A1
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 6 p. 1418 - 1422
  • Route3
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      6-Chloronicotinic acid|CS-D1204
      5326-23-8
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      6-Hydrazinylnicotinic acid|CS-W003107
      133081-24-0
    • 6-Hydrazinylnicotinohydrazide|CS-0670943
      731005-24-6

    References

    • Chemische Berichte, , vol. 36, p. 1114

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   88.24
  • LogP   0.0654
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   2

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