3-Bromo-5-fluoro-4-methylpyridine

Name: 3-Bromo-5-fluoro-4-methylpyridine
Brand: ChemScene
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CAS No. 1211517-76-8
Cat. No. CS-W006965
Molecule weight190.01
Purity≥96%
MDL No.MFCD18257616

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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3-Bromo-5-fluoro-4-methylpyridine|CS-W006965

Structure of 1211517-76-8

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General Information

CAS No. 1211517-76-8
Cat. No. CS-W006965
Purity ≥96%
MDL No. MFCD18257616
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrFN
Molecular Weight 190.01
Synonym(s) 3-BroMo-5fluoro-4-Methylpyridine
SMILES CC1=C(Br)C=NC=C1F

Description

3-Bromo-5-fluoro-4-methylpyridine features a pyridine core with strategically positioned halogen and methyl groups, enabling selective cross-coupling reactions. The electron-deficient ring facilitates palladium-catalyzed transformations, while the ortho-bromine serves as a high-reactivity handle for C–C bond formation under mild conditions. This bench-stable building block supports efficient synthesis of functionalized heterocycles in medicinal chemistry and materials science.

Application

3-Bromo-5-fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen and electron-withdrawing fluorine substituents. The methyl group provides a handle for further functionalization, while the pyridine core offers robust stability and predictable reactivity in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  407-20-5
- 74-88-4
- ~51%
- In-stock
  
  1211517-76-8
References
- Hoffmann-La Roche Inc.; Alam, Muzaffar; DuBois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Thakkar, Kshitij Chhabilbhai; Wilhelm, Robert Stephen Patent: US2013/109720 A1, 2013 ; Location in patent: Paragraph 0092; 0093 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.29162
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-5-fluoro-4-methylpyridine

CAS No. 1211517-76-8

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