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CS-W001157 4
Total: USD 88.00

3-Bromo-5-methylpicolinic acid

  • CAS No. 1211515-68-2

  • Cat. No. CS-0030549
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-methylpicolinic acid|CS-0030549

Structure of 1211515-68-2

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General Information

  • CAS No. 1211515-68-2
  • Cat. No. CS-0030549
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) 3-Bromo-5-methylpyridine-2-carboxylic acid; 3-Bromo-5-methylpicolinic acid
  • SMILES O=C(C1=NC=C(C)C=C1Br)O

Description

3-Bromo-5-methylpicolinic acid features a brominated pyridine core with a methyl group at the 5-position, enabling direct functionalization in cross-coupling reactions. The carboxylic acid moiety provides a robust anchor for peptide coupling and conjugation workflows. This bench-stable derivative offers enhanced reactivity compared to unsubstituted analogs, facilitating efficient access to complex heterocyclic architectures under standard conditions.

Application

3-Bromo-5-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of bromo and methyl groups into heterocyclic scaffolds. Its ortho-brominated pyridine core facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group supports facile derivatization via amide or ester formation. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it well-suited for modular synthesis of bioactive molecules and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.85072
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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