7-Bromo-5-fluoroquinoxaline

Name: 7-Bromo-5-fluoroquinoxaline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1210048-05-7
Cat. No. CS-0041912
Purity≥98%
MDL No.MFCD19053255

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1210048-05-7

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General Information

CAS No. 1210048-05-7
Cat. No. CS-0041912
Purity ≥98%
MDL No. MFCD19053255
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄BrFN₂
Molecular Weight 227.03
Synonym(s) 7-Bromo-5-fluoro-1,4-benzodiazine
SMILES FC1=C2N=CC=NC2=CC(Br)=C1

Description

7-Bromo-5-fluoroquinoxaline is a heterocyclic aromatic compound featuring strategically positioned bromo and fluoro substituents that enhance reactivity in cross-coupling processes. This electron-deficient scaffold facilitates efficient palladium-catalyzed transformations, enabling rapid access to complex quinoxaline-based architectures. The molecule exhibits excellent stability under standard conditions and serves as a key building block in the synthesis of functional materials and bioactive molecules.

Application

7-Bromo-5-fluoroquinoxaline serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluoro substituent offers enhanced electrophilicity for nucleophilic aromatic substitution. Its bench-stable nature and orthogonal reactivity profile make it ideal for sequential functionalization in complex molecule synthesis.

Synthesis

Route1
- 4845-50-5
- In-stock
  
  517920-69-3
- ~79%
- In-stock
  
  1210048-05-7
References
- BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan Patent: WO2010/20363 A1, 2010 ; Location in patent: Page/Page column 117 ;
Route2
- 131543-46-9
- In-stock
  
  517920-69-3
- ~%
- In-stock
  
  1210048-05-7
References
- UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne Patent: WO2010/52448 A2, 2010 ; Location in patent: Page/Page column 70 ; WO 2010/052448 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 2.5314
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Quinoxaline compounds

Key Words

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7-Bromo-5-fluoroquinoxaline

CAS No. 1210048-05-7

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