2-Bromo-5-(trifluoromethyl)thiazole

Name: 2-Bromo-5-(trifluoromethyl)thiazole
Brand: ChemScene
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CAS No. 1209458-80-9
Cat. No. CS-0041805
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-5-(trifluoromethyl)thiazole|CS-0041805

Structure of 1209458-80-9

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General Information

CAS No. 1209458-80-9
Cat. No. CS-0041805
Purity ≥96%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄HBrF₃NS
Molecular Weight 232.02
Synonym(s) 2-Bromo-5-(trifluoromethyl)-1,3-thiazole
SMILES FC(C1=CN=C(Br)S1)(F)F

Description

2-Bromo-5-(trifluoromethyl)thiazole is a halogenated thiazole derivative featuring a trifluoromethyl group at the 5-position and a bromine atom at the 2-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient coupling reactions for constructing bioactive molecules. The trifluoromethyl moiety enhances metabolic stability and lipophilicity, while the bromine facilitates further functionalization via cross-coupling protocols.

Application

2-Bromo-5-(trifluoromethyl)thiazole serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable halogen functionality. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the thiazole core provides a privileged scaffold for bioactive molecules. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient incorporation into complex molecular architectures.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.9244
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2-Bromo-5-(trifluoromethyl)thiazole

CAS No. 1209458-80-9

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