1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid

Name: 1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1208087-83-5
Cat. No. CS-0155580
Purity≥98%
MDL No.MFCD11040198

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid|CS-0155580

Structure of 1208087-83-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1208087-83-5
Cat. No. CS-0155580
Purity ≥98%
MDL No. MFCD11040198
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂ClN₃O₂
Molecular Weight 241.67
Synonym(s) 1-(2-Chloro-4-pyrimidinyl)-4-piperidinecarboxylic Acid
SMILES C1=CN=C(Cl)N=C1N2CCC(CC2)C(=O)O

Description

This piperidine-based scaffold integrates a 2-chloropyrimidin-4-yl group, delivering enhanced electrophilic reactivity and metabolic stability. The carboxylic acid functionality enables direct conjugation or salt formation, supporting efficient derivatization in medicinal chemistry campaigns. Designed for robust performance under standard bench conditions.

Application

1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles, particularly in medicinal chemistry and agrochemical research. The molecule combines a reactive 2-chloropyrimidine moiety with a piperidine carboxylic acid scaffold, enabling efficient coupling reactions via nucleophilic substitution or amide formation. Its bench-stable nature, predictable reactivity, and compatibility with standard purification methods make it well-suited for modular synthesis workflows.

Synthesis

Route1
- In-stock
  
  1126-09-6
- ~%
- In-stock
  
  1208087-83-5
References
- MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha Patent: WO2013/41457 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 66.32
LogP 1.431
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

1208087-83-5 sigma1208087-83-5 manufacturer1208087-83-5 price1208087-83-5 structure1208087-83-5 SDSbuy 1208087-83-51208087-83-5 supplier1208087-83-5 uses1208087-83-5 molecular weightprice of 1208087-83-51208087-83-5 chemical name formula of 1208087-83-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid

CAS No. 1208087-83-5

Recommended Products