2-Chloro-5-methylpyridine-3-sulfonyl chloride

Name: 2-Chloro-5-methylpyridine-3-sulfonyl chloride
Brand: ChemScene
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CAS No. 1208081-98-4
Cat. No. CS-0378258
Purity≥98%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-5-methylpyridine-3-sulfonyl chloride|CS-0378258

Structure of 1208081-98-4

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General Information

CAS No. 1208081-98-4
Cat. No. CS-0378258
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅Cl₂NO₂S
Molecular Weight 226.08
Synonym(s) 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride
SMILES O=S(Cl)(C1=CC(C)=CN=C1Cl)=O

Description

2-Chloro-5-methylpyridine-3-sulfonyl chloride features a reactive sulfonyl chloride group flanked by electron-withdrawing chlorine and methyl-substituted pyridine moieties. This configuration enhances electrophilicity for efficient coupling reactions in synthetic medicinal chemistry, enabling direct incorporation into pharmaceutical intermediates under mild conditions.

Application

2-Chloro-5-methylpyridine-3-sulfonyl chloride serves as a versatile sulfonyl chloride building block for the construction of sulfonamide-containing heterocycles. Its reactivity is well-established in amide and sulfonamide formation, enabling efficient functionalization under mild conditions. The pyridine core provides stability and orthogonal reactivity, while the methyl group enhances solubility and influences electronic properties. Ideal for medicinal chemistry campaigns requiring targeted sulfonamide incorporation, it facilitates straightforward purification and scale-up compatibility.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 47.03
LogP 1.97092
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-methylpyridine-3-sulfonyl chloride

CAS No. 1208081-98-4

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