2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine

Name: 2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine
Brand: ChemScene
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CAS No. 1207665-87-9
Cat. No. CS-0565881
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine|CS-0565881

Structure of 1207665-87-9

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General Information

CAS No. 1207665-87-9
Cat. No. CS-0565881
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClF₄N
Molecular Weight 199.53
Synonym(s) None
SMILES FC(C1=CC(Cl)=NC(F)=C1)(F)F

Description

2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine features a highly electron-deficient pyridine core, enabling efficient coupling in cross-coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the ortho-chloro and para-fluoro substituents facilitate directed functionalization. This bench-stable scaffold integrates readily into complex molecular architectures for pharmaceutical and agrochemical applications.

Application

2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its activated C–Cl bond. The trifluoromethyl and fluorine substituents enhance metabolic stability and modulate electronic properties, while the pyridine core provides a rigid scaffold for targeted drug discovery. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex heterocyclic architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H227-H301-H315-H319
Precautionary Statements : P210-P264-P270-P280-P302+P352-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 2.8929
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine

CAS No. 1207665-87-9

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