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6-Chloro-3-fluoropicolinonitrile

  • CAS No. 1207609-52-6

  • Cat. No. CS-0097098
  • Molecule weight156.54
  • Purity≥98%
  • MDL No.MFCD18250470

*For research and further manufacturing use only, not for direct human use.

6-Chloro-3-fluoropicolinonitrile|CS-0097098

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General Information

  • CAS No. 1207609-52-6
  • Cat. No. CS-0097098
  • Purity ≥98%
  • MDL No. MFCD18250470
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClFN₂
  • Molecular Weight 156.54
  • Synonym(s) 6-Chloro-3-fluoro-pyridine-2-carbonitrile
  • SMILES N#CC1=NC(Cl)=CC=C1F

Description

6-Chloro-3-fluoropicolinonitrile is a fluorinated nitrile derivative featuring complementary electron-withdrawing substituents at the 3- and 6-positions of the pyridine ring. This configuration enhances electrophilicity at the C2 carbon, enabling efficient coupling in cross-coupling reactions. The molecule exhibits high stability under standard conditions and facilitates the synthesis of complex heterocyclic scaffolds in medicinal chemistry and agrochemical development.

Application

6-Chloro-3-fluoropicolinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds via nucleophilic substitution and cyclization reactions. Its orthogonal reactivity profile—combining a nitrile group with strategically positioned chlorine and fluorine substituents—facilitates downstream functionalization while maintaining bench stability and compatibility with standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.74578
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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